| ncRNA name | mmu-miR-34a |
| ncRNA Category | miRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Mus musculus |
| Tissues/Cell_line | C8B4 murine microglial (MG) cell lines: MAC1, F4/80, 2-4G2, Iba1 and TREM2 (but not GFAP) |
| Methods | transfection, miRNA array, RT-PCR, Western blot, luciferase reporter assay |
| Expression pattern | up-regulated |
| Functional description | Up-regulation of a microglial-enriched NF-кB-sensitive miRNA-34a coupled to a down-regulation of TREM2 in the same samples. Bioinformatics/transfection-luciferase reporter assays indicated that miRNA-34a targets the 299 nucleotide TREM2-mRNA-3'UTR, resulting in TREM2 down-regulation. |
| PubMed ID | 26949937 |
| Year | 2016 |
| Title | microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration. |
| Drug-related ncRNA | NO |
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